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eTMF

Electronic Trial Master File

MAESTRO eTMF delivers real-time inspection readiness with intuitive document management, automated workflows, and comprehensive compliance controls designed for modern clinical research.

eTMF for Health Canada-compliant clinical trials with 21 CFR Part 11 e-signatures
Capabilities

Complete document management.

Transform clinical trial documentation from compliance burden to strategic asset — intuitive, searchable, and inspection-ready at all times.

Document Management

  • Comprehensive DIA Reference Model support with full TMF structure
  • Intelligent document classification and auto-filing
  • Robust version control and document history tracking
  • Advanced search with metadata, full-text, and OCR capabilities
  • Customizable templates for consistent document creation

Regulatory Compliance

  • 21 CFR Part 11 compliant electronic signatures
  • Automated audit trails with complete user action logging
  • Real-time compliance validations and gap analysis
  • Configurable retention policies with secure archiving
  • Inspection-ready reporting with one-click access

Workflow Automation

  • Automated document request workflows with tracking
  • Configurable review and approval processes
  • Intelligent document expiry notifications and renewals
  • Automated quality control checks and validations
  • Site-specific document collection and management

Inspection Readiness

  • Real-time completeness tracking with visual dashboards
  • Automated identification of missing or expiring documents
  • Inspection-ready views with custom access portals
  • Comprehensive metrics and analytics on documentation status
  • Remote inspector access with secure, read-only permissions

Document Exchange

  • Secure portal for sponsor-site document exchange
  • Automated notifications for document requests
  • Bulk document upload and download capabilities
  • Multi-party collaborative document review
  • Comprehensive chain of custody tracking

Interoperability

  • Open API for third-party system integration
  • EHR/EDC document connector for streamlined data flow
  • Automated import from email and shared drives
  • Standardized document exchange (CDISC, HL7 FHIR)
  • CRO and vendor collaboration tools
Outcomes

eTMF benefits.

99%

Inspection readiness

Maintain perpetual inspection readiness with real-time completeness tracking.

75%

Reduced documentation time

Slash document processing time with intelligent automation and workflows.

60%

Fewer document queries

Automated quality controls catch issues before they become audit findings.

100%

Regulatory compliance

Meet global regulatory requirements with built-in compliance controls.

Better together

Seamless integration with MAESTRO.

MAESTRO eTMF connects natively with CTMS, QMS, Workflow and AI Agents — one unified trial documentation experience.

eTMF + CTMS

Documents automatically link to their corresponding studies, sites, and activities, creating a complete trial context with bi-directional navigation.

eTMF + QMS

Quality events trigger appropriate documentation updates, ensuring consistency between quality processes and trial documentation.

eTMF + Workflow

Customizable workflows automate document collection, review, and approval processes with role-based assignments and deadlines.

eTMF + AI Agents

AI-powered document classification, metadata extraction, and quality checks dramatically reduce manual document processing time.

Ready when you are

See MAESTRO eTMF in action.

Join organizations achieving real-time inspection readiness, automated document workflows, and complete compliance control — all while saving hours daily per team member.

Book your discovery call